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Syed M. Nurulain, Georg Petroianu, Mohamed Shafiullah, Huba Kalász, Murat Oz, Tariq Saeed, Abdu Adem and Ernest Adeghate Sub-chronic exposure to paraoxon neither induces nor exacerbates diabetes mellitus in Wistar rat Journal of Applied Toxicology 33

Article first published online: 9 AUG 2012 | DOI: 10.1002/jat.2794

There is an increasing belief that organophosphorus compounds (OPCs) impair glucose homeostasis and cause hyperglycemia and diabetes mellitus. The present study was undertaken to investigate the putative diabetogenic effect of sub-lethal and sub-chronic exposure of paraoxon, an extremely hazardous OPC used in pesticides. The effect of paraoxon on streptozotocin-induced diabetic rats was also examined. The results suggest that paraoxon neither induces nor exacerbates diabetes in experimental rats.

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