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Darol E. Dodd, Linda J. Pluta, Mark A. Sochaski, Kathleen A. Funk and Russell S. Thomas Subchronic urinary bladder toxicity evaluation of N-Nitrosodiphenylamine in Fischer 344 rats Journal of Applied Toxicology 33

Version of Record online: 14 AUG 2012 | DOI: 10.1002/jat.2798

Female Fischer 344 (F344) rats were exposed to N-nitrosodiphenylamine (NDPA) at feed concentrations of 0, 250, 1000, 2000, 3000 or 4000 ppm for 5 days, 2, 4 and 13 weeks. Increases in urinary bladder weight occurred at ≥ 3000 ppm. Urinary bladder microscopic alterations of mixed cell infiltrates, increased mitosis, necrosis of epithelial cells, and transitional epithelial hyperplasia and squamous metaplasia were observed at ≥ 2000 ppm. A no observable adverse effect level (NOAEL) of 1000 ppm NDPA (60 mg kg–1 day–1) was selected.

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