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Chad M. Thompson, David W. Gaylor, J. Andrew Tachovsky, Camarie Perry, Michael C. Carakostas and Laurie C. Haws Development of a chronic noncancer oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling Journal of Applied Toxicology 33

Version of Record online: 31 AUG 2012 | DOI: 10.1002/jat.2799

Sulfolane is a widely used industrial solvent that is often used for gas treatment, in the manufacture of polymers and electronics, and may be found in pharmaceuticals as a residual solvent. The lowest, most conservative, RfD of 0.01 mg kg−1 per day was based on reduced white blood cell counts in female rats. This RfD was used to develop a tap water screening level that is protective of ingestion, viz. 365 µg l−1.

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