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Tessa E. Pronk, Eugene P. van Someren, Rob H. Stierum, Janine Ezendam and Jeroen L.A. Pennings Unraveling toxicological mechanisms and predicting toxicity classes with gene dysregulation networks Journal of Applied Toxicology 33

Version of Record online: 10 AUG 2012 | DOI: 10.1002/jat.2800

In this paper we combine network reconstruction with classification of unseen compounds to their appropriate toxicity class. We select gene pairs that are linked by a common expression pattern in one class and differ in this expression pattern in another class. The resulting gene dysregulation network provides novel and well-distinguishing pairs of markers. Moreover, paired expressions by their specific pattern generate new hypotheses on regulatory origin and/or common functionality of genes in the pairs, and how these differ between classes.

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