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Ioanna Vasileiou, Demetrios Patsouras, Efstratios Patsouris and Stamatios Theocharis Ghrelin and toxicity: recent findings and future challenges Journal of Applied Toxicology 33

Version of Record online: 10 AUG 2012 | DOI: 10.1002/jat.2803

Ghrelin is a novel brain–gut peptide that plays various roles in mammals, including control of food intake and growth hormone release, as well as gastric motility and acid secretion in the gastrointestinal tract. Evidence exists supporting ghrelin's antiapoptotic actions and its protective effects against drug-induced toxicity and ischemia–reperfusion injury in different organs. In the current review, the available regarding ghrelin and its effects on different modes of target tissue injury are summarized.

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