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Bing Wu, Su Liu, Shupei Cheng, Yan Zhang and Xuxiang Zhang Hepatic gene expression analysis of mice exposed to raw water from Meiliang Bay, Lake Taihu, China Journal of Applied Toxicology 33

Version of Record online: 17 AUG 2012 | DOI: 10.1002/jat.2805

Male mice were exposed to raw water from Meiliang Bay, Lake Taihu, China for 90 days. Hepatic transcriptomic profiles were determined. Compared with control group, raw water altered expression of 170 hepatic genes. Nine biological processes and nine biological pathways were significantly perturbed, mainly linked to the regulation of cell processes, DNA repair, chromatin modification, oxidative reduction and carbohydrate metabolism. This study provided excellent insights into early toxicological effects related to raw Lake Taihu water.

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