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Zongmei Wen, Yan Liu, Feng Li and Tao Wen Low dose of carbon monoxide intraperitoneal injection provides potent protection against GalN/LPS-induced acute liver injury in mice Journal of Applied Toxicology 33

Version of Record online: 27 SEP 2012 | DOI: 10.1002/jat.2806

The protective effects of exogenous CO via intraperitoneal injection were investigated in a murine model of acute liver damage induced by GalN/LPS. It showed that CO remarkably improved the survival rate of mice and led to attenuated hepatocellular damage. CO inhibits hepatic MDA contents and restores SOD and GSH, as well as reducing iNOS/NO production. Additionally, CO substantially inhibits hepatocyte apoptosis and reduces pro-inflammatory cytokines levels. Thus, the protective effects of CO are mainly dependent on its anti-oxidative, anti-inflammatory and anti-apoptotic properties.

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