Chengyu Jin, Yumin Liu, Limin Sun, Tianlu Chen, Yinan Zhang, Aihua Zhao, Xiaoyan Wang, Melanie Cristau, Kaisheng Wang and Wei Jia Metabolic profiling reveals disorder of carbohydrate metabolism in mouse fibroblast cells induced by titanium dioxide nanoparticles Journal of Applied Toxicology 33
In this study, the cytotoxicity of TiO2 nanoparticles was investigated by analyzing the changes in metabolite profiles both in mouse fibroblast (L929) cells and their corresponding culture media using gas chromatograph with a time-of-flight mass spectrometry (GC/TOFMS)-based metabolomic strategy. It was found that the major biochemical metabolism (carbohydrate metabolism) was suppressed in TiO2 nanoparticle-treated L929 cells and their corresponding culture media. These results might account for the serious damage to energy metabolism in mitochondria and the increased cellular oxidation stress in TiO2 nanoparticle-induced L929 cells.
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