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Eiko Koike, Rie Yanagisawa, Hidetaka Takigami and Hirohisa Takano Brominated flame retardants stimulate mouse immune cells in vitro Journal of Applied Toxicology 33

Version of Record online: 12 SEP 2012 | DOI: 10.1002/jat.2809

Brominated flame retardants (BFRs) are widely used in consumer products. To evaluate the effects of BFRs on immune responses, we investigated whether BFRs affect phenotypes and the function of splenocytes and bone marrow-derived dendritic cells in vitro. Polybrominated diphenyl ethers, hexabromocyclododecane, and tetrabromobisphenol A were examined. The results demonstrate that some BFRs may stimulate immune cells. BFRs can induce or enhance immune/allergic responses by increasing antigen presentation-related molecule expression and interleukin-4 production.

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