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Makoto Ema, Shoji Masumori, Norihiro Kobayashi, Masato Naya, Shigehisa Endoh, Junko Maru, Masayo Hosoi, Fuyumi Uno, Madoka Nakajima, Makoto Hayashi and Junko Nakanishi In vivo comet assay of multi-walled carbon nanotubes using lung cells of rats intratracheally instilled Journal of Applied Toxicology 33

Version of Record online: 31 AUG 2012 | DOI: 10.1002/jat.2810

Multi-walled carbon nanotubes (MWCNTs) were intratracheally instilled as a single dose at 0.2 or 1.0 mg kg–1 or a repeated dose at 0.04 or 0.2 mg kg–1, once a week for 5 weeks, to male rats. Inflammatory changes were found in the lungs of rats after a single instillation and repeated instillation at both doses. MWCNTs had no potential for DNA damage in comet assays using the lung cells of rats given MWCNTs at doses causing inflammatory responses.

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