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Tamanna Zerin, Yong-Sik Kim, Sae-Yong Hong and Ho-Yeon Song Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells Journal of Applied Toxicology 33

Version of Record online: 20 SEP 2012 | DOI: 10.1002/jat.2812

We examined quercetin-mediated changes in the expression of genes associated with oxidative stress and antioxidant defense in A549 type II-like alveolar epithelial cells exposed to PQ. Quercetin was shown to attenuate PQ-induced oxidative damage in alveolar A549 cells through the activation of the transcription factor Nrf2, induction of its target HO-1 expression and other antioxidant-related genes, which ultimately improves cell viability by reducing cellular ROS and increasing cellular GSH. These combined results indicate that quercetin may be used to mitigate or minimize oxidative stress via reduction of oxygen radicals.

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