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Su-Eun Han, Mi-Gyeong Kim, Soondong Lee, Hee-Jeong Cho, Youngro Byun, Sujeong Kim, Young Bong Kim, Yongseok Choi and Yu-Kyoung Oh Initial preclinical safety of non-replicating human endogenous retrovirus envelope protein-coated baculovirus vector-based vaccines against human papillomavirus Journal of Applied Toxicology 33

Article first published online: 14 SEP 2012 | DOI: 10.1002/jat.2815

Human endogenous retrovirus (HERV) envelope protein-coated, baculovirus vector-based HPV16L1 (AcHERV-HPV16L1) is a non-replicating DNA vaccine. AcHERV-HPV16L1 DNA vaccine did not cause significant changes in body weight. No hematological changes were observed on day 30 post-treatment. In a repeated-dose toxicity study, a transient decrease in the body weights was recovered by post-treatment day 20. Organ weights had normalized by day 30. A AcHERV-based HPV16L1 DNA vaccine demonstrated preclinical safety criteria in acute and range-finding toxicity studies.

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