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Yongkun Sun, Zhikun Guo, Shouhei Iku, Takeshi Saito and Masaaki Kurasaki Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells Journal of Applied Toxicology 33

Article first published online: 11 SEP 2012 | DOI: 10.1002/jat.2816

We investigate whether diethyl phthalate, one of the potential endocrine disrupters, affect sirtuins (SIRT1 and SIRT2) and methyltranferases (DNMT1 and DNMT3a) on the apoptosis of PC12 cells, because diethyl phthalate was reported previously to enhance apoptosis induced by serum deprivation. We found that DNMT3a was significantly decreased by serum deprivation. However, DNMT3a, DNMT3b and SIRT1were significantly increased under the enhancement of apoptosis induced by serum deprivation. These results suggest that SIRT1, DNMT3a and DNMT3b play multiple and complex roles in different apoptotic stages.

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