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Norma Rivera, Marcela Rojas, Armando Zepeda, Filiberto Malagón, Vicente J. Arán, Yovani Marrero-Ponce, Ernesto Rivera and Teresa I. Fortoul In vivo genotoxicity and cytotoxicity assessment of a novel quinoxalinone with trichomonacide activity Journal of Applied Toxicology 33

Article first published online: 10 OCT 2012 | DOI: 10.1002/jat.2819

Compound VAM2-6, a 7-nitro-4-(5-piperidinopentyl)quinoxalin-2-one, has been shown previously to exhibit an in vitro trichomonacide efficacy of 100% at a concentration of 100 µg ml–1. The present study was undertaken to evaluate its ability to induce DNA damage in the peripheral blood of mice using the comet and micronucleus assays. Cell viability was assessed by the fluorochrome-mediated viability test. VAM2-6 induced DNA damage in a dose-dependent manner and decreased cell viability 24 h after treatment.

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