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Xiaoying Hui, Sonia Lamel, Peter Qiao and Howard I. Maibach Isolated human/animal stratum corneum as a partial model for 15 steps in percutaneous absorption: emphasizing decontamination, Part I Journal of Applied Toxicology 33

Article first published online: 30 OCT 2012 | DOI: 10.1002/jat.2821

Since the advent of World War II, governments and laboratories have made a concerted effort to improve prophylactic and therapeutic interventions counteracting cutaneously directed chemical warfare agents (CWA), and by inference, common dermatotoxicants. In vitro percutaneous penetration assays, first utilized by Tregear in the 1940s, have been fundamental to this effort. The first part of this review summarizes knowledge of percutaneous penetration extending insights into the complexities of penetration and potential newer assays that may be of practical importance

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