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Kelsi Hurt, Tasia Hurd-Brown and Margaret Whalen Tributyltin and dibutyltin alter secretion of tumor necrosis factor alpha from human natural killer cells and a mixture of T cells and natural killer cells Journal of Applied Toxicology 33

Version of Record online: 10 OCT 2012 | DOI: 10.1002/jat.2822

Human natural killer (NK) cells and a mixture of T and NK (T/NK) cells were exposed to tributyltin (TBT) (200 - 2.5 nM) and dibutyltin (DBT) (5 -  0.05 μM) for 24 h, 48 h, and 6 day. TBT (200 - 2.5 nM) decreased TNFα secretion from NK cells. 200 nM TBT decreased secretion while 100 - 5 nM TBT increased secretion in T/NK cells. DBT (high concentration) decreased TNFα secretion while lower concentrations increased secretion in both NK cells and T/NK cells.

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