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Rafael Palhano Fedato and Edson Luis Maistro Absence of genotoxic effects of the coumarin derivative 4-methylesculetin in vivo and its potential chemoprevention against doxorubicin-induced DNA damage Journal of Applied Toxicology 34

Article first published online: 10 OCT 2012 | DOI: 10.1002/jat.2823

4-Methylesculetin (4-ME) is a potent synthetic antioxidant compound. This study investigated the in vivo genotoxicity of 4-ME and its potential antigenotoxicity against doxorubicin (DX) DNA damage. Doses of 500, 1000 and 2000 mg kg–1 were tested only or with a simultaneous injection of DX. A comet assay in different cells of mice and the micronucleus test were the endpoints analyzed. No differences were observed between the control and treated groups, indicating that it lacks genotoxic and cytotoxic effects. Moreover, 4-ME demonstrated protective effects against DX.

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