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K. A. Brown, T. Mays, A. Romoser, A. Marroquin-Cardona, N. J. Mitchell, S. E. Elmore and T. D. Phillips Modified hydra bioassay to evaluate the toxicity of multiple mycotoxins and predict the detoxification efficacy of a clay-based sorbent Journal of Applied Toxicology 34

Article first published online: 10 OCT 2012 | DOI: 10.1002/jat.2824

Mycotoxin sorption efficacy of UPSN, a refined calcium montmorillonite clay, was examined in vitro and a rapid in vivo hydra bioassay was utilized to evaluate aflatoxin B1 and fumonisin B1 toxicity and confirm UPSN efficacy. UPSN sorbed both mycotoxins in vitro, although more FB1 bound at pH 2.0 than 6.5. Treatment with UPSN resulted in significant protection to mycotoxin-exposed hydra. Results indicate that this modified hydra bioassay can be used as an initial screen to predict toxin binding agent efficacy.

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