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Yu Yamaguchi, Eiko Sakai, Hiroshi Sakamoto, Reiko Fumimoto, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto and Takayuki Tsukuba Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression Journal of Applied Toxicology 34

Version of Record online: 30 OCT 2012 | DOI: 10.1002/jat.2827

Osteoclasts (OCLs) are multinucleated bone-resorbing cells. In this study, we investigated the effects of tert-butylhydroquinone (tBHQ) on differentiation of macrophages into OCLs. tBHQ treatment decreased the expression of nuclear factor of activated T cells cytoplasmic-1 (NFATc1) and impaired phosphorylation of several mitogen-activated protein kinases. And, tBHQ inhibited the release of high mobility group box 1 (HMGB1), a recently identified activator of OCL differentiation. Thus, tBHQ inhibits OCL differentiation through the HO-1/HMGB1/NFATc1 pathways.

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