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Panagiotis Zogopoulos, Ioanna Vasileiou, Efstratios Patsouris and Stamatios Theocharis The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects Journal of Applied Toxicology 33

Article first published online: 8 JAN 2013 | DOI: 10.1002/jat.2828

The endocannabinoid system and especially its ligands, the endocanabinoids, have received increasing attention as potential neuroprotective agents against chemical-induced injury and other adverse effects. Endocannabinoids serve as retrograde signalling messengers in GABAergic and glutamatergic synapses, as well as modulators of post-synaptic transmission, interacting with other neurotransmitters, including norepinephrine and dopamine. Furthermore, they exert neuromodulatory, anti-excitotoxic, anti-inflammatory and vasodilatory effects. We present here recent data regarding the protecting role of endocannabinoids in cases of neurotoxicity.

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