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Toshio Imai and Tsukasa Kitahashi A 13-week toxicity study of acrylamide administered in drinking water to hamsters Journal of Applied Toxicology 34

Article first published online: 6 NOV 2012 | DOI: 10.1002/jat.2831

Thirteen-week toxicity of (AA) was evaluated in Syrian hamsters, at concentrations of 0 (control), 20, 30 and 50 mg kg–1 body weight in drinking water. Treatment with AA caused peripheral nerve disorders in all AA-treated groups with dose dependence. In addition, testicular toxicity at 50 mg kg–1 and lowered body weights at 30 and 50 mg kg–1 were observed. These results indicated the maximum tolerated dose for long-term studies of AA to be 20 mg kg–1 or less in Syrian hamsters.

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