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Debasish Halder, Ji Hyun Park, Mi Ran Choi, Jin Choul Chai, Young Seek Lee, Chanchal Mandal, Kyoung Hwa Jung and Young Gyu Chai Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation Journal of Applied Toxicology 34

Article first published online: 4 FEB 2013 | DOI: 10.1002/jat.2832

In the present study, we examined the role that chronic ethanol (EtOH) exposure plays in gene expression changes during early stage of embryonic differentiation. By employing a transcriptomic approach, we have identified genes, including GSC, which are vulnerable to EtOH exposure during the early stages of embryonic development. We reported that EtOH deregulates GSC expression by altering nodal signaling pathway, which may provide a new avenue for analyzing the molecular mechanisms behind EtOH teratogenicity in FASD individuals.

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