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Tin-Tin Win-Shwe, Rie Yanagisawa, Eiko Koike, Hiroshi Nitta and Hirohisa Takano Expression levels of neuroimmune biomarkers in hypothalamus of allergic mice after phthalate exposure Journal of Applied Toxicology 33

Version of Record online: 13 NOV 2012 | DOI: 10.1002/jat.2835

Previously, we demonstrated that maternal exposure to phthalates enhances atopic dermatitis in male mouse offspring. However, whether phthalate exposure affects neuroimmune biomarkers in allergic mice has not yet been studied. Di-(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DINP) are environmental chemicals that are commonly used as plasticizers. This study was designed to investigate the expression levels of neuroimmune biomarkers in the hypothalamus of a murine model of allergic asthma after phthalate exposure throughout juvenility until adulthood.

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