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Cristiani F. Bortolatto, Ethel A. Wilhelm, Silvane S. Roman and Cristina W. Nogueira (E)-2-Benzylidene-4-phenyl-1,3-diselenole ameliorates signals of renal injury induced by cisplatin in rats Journal of Applied Toxicology 34

Article first published online: 10 DEC 2012 | DOI: 10.1002/jat.2837

The protective effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD) on renal injury induced by cisplatin in rats was investigated. BPD ameliorated renal injury and reduced plasma markers altered by cisplatin. BPD attenuated the reduction of renal AA and GSH content induced by cisplatin. The decrease of GST activity, but not GPx and CAT activities, in rats exposed to cisplatin was reversed by BPD. BPD was effective in attenuating the inhibition of δ-aminolevulinic dehydratase in kidneys of rats exposed to cisplatin.

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