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Shashank Masaldan and Vidhya V. Iyer Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions Journal of Applied Toxicology 34

Version of Record online: 5 DEC 2012 | DOI: 10.1002/jat.2838

Ascorbic acid (AA) pre-treatment increased growth inhibition by emodin in AR-positive LNCaP, PC-3, HCT-15, MG-63 and A549 cancer cells, all with varying LRP1 levels, probably owing to ROS generation by emodin and the pro-oxidant activity of AA. Marked increase in LRP1 expression and growth inhibition of these cancer cells by emodin under hypoxia-like conditions may point to a strategy to target hypoxic tumors through the LRP1 protein by increased uptake of emodin, alone or along with other chemotherapeutic agents.

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