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Lifeng Gao, Sheng-Tao Yang, Shaorui Li, Yuguang Meng, Haifang Wang and Hao Lei Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation Journal of Applied Toxicology 33

Article first published online: 11 JAN 2013 | DOI: 10.1002/jat.2842

ZnO nanoparticles are mass-produced nanomaterials. In this study, we evaluated the acute toxic effects of 30 nm-diameter ZnO nanoparticles after intranasal instillation by behavioral tests, magnetic resonance imaging and histology. It was shown ZnO nanoparticles instilled into the nasal cavity caused significant structural damages to rat olfactory epithelium (OE) and olfactory impairment. ZnO NP-induced OE damages are characterized by edema, degeneration of epithelial cells and increased blood vessel permeability. The possible toxicological mechanism might involve cellular energy metabolic dysfunction.

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