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Giel Hendriks, Bob van de Water, Willem Schoonen and Harry Vrieling Cellular-signaling pathways unveil the carcinogenic potential of chemicals Journal of Applied Toxicology 33

Article first published online: 22 JAN 2013 | DOI: 10.1002/jat.2845

Upon chemical-induced damage of biomolecules, molecular sensors will activate general and damage-specific cellular response pathways that provide protection against the (geno)toxic and potential carcinogenic properties of chemicals. visualization of the cellular signaling pathways that are activated upon exposure provides a powerful means to identify the primary mode of action of (geno)toxic compounds and will improve the in vitro health risk and carcinogenicity hazard prediction.

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