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Satomi Onoue, Masashi Kato and Shizuo Yamada Development of an albuminous reactive oxygen species assay for photosafety evaluation under experimental biomimetic conditions Journal of Applied Toxicology 34

Version of Record online: 28 JAN 2013 | DOI: 10.1002/jat.2846

A new reactive oxygen species (ROS) assay using serum albumin (aROS assay) was developed for photosafety assessment in biomimetic solution, and validation study demonstrated the high robustness of the aROS assay and improved applicability to poorly soluble chemicals. Assessments on 31 test samples were also indicative of good predictive capacity of the aROS assay. The aROS assay may allow photosafety assessment of new drug entities with a wide range of applicability partly under experimental biomimetic conditions.

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