K. D. Welch, B. T. Green, K. E. Panter, J. A. Pfister and D. R. Gardner The role of the α7 subunit of the nicotinic acetylcholine receptor in the acute toxicosis of methyllycaconitine in mice Journal of Applied Toxicology 33
The adverse effects of methyllycaconitine (MLA) have been attributed to its competitive antagonism of nicotinic acetylcholine receptors (nAChRs). The objective of this study was to characterize the role of the α7 subunit of nAChRs in the acute toxicosis of MLA by comparing the lethal dose (LD50) of MLA in wild-type mice to mice lacking the α7 subunit. The results from this study suggest that the α7 nAChR does not play an integral role in the acute toxicosis of MLA.
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