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Katsuya Unno, Kurumi Yamoto, Kouhei Takeuchi, Aya Kataoka, Tomoya Ozaki, Takatoshi Mochizuki, Kazuki Honda, Nobuhiko Miura and Masayuki Ikeda Acute enhancement of non-rapid eye movement sleep in rats after drinking water contaminated with cadmium chloride Journal of Applied Toxicology 34

Article first published online: 24 JAN 2013 | DOI: 10.1002/jat.2853

Drinking water contaminated with 100 ppm CdCl2 promoted non-rapid-eye-movement (REM) sleep and reduced locomotor activities during the active phase of rats. The duration of CdCl2 exposure required to modify these behaviors (28 h) was far shorter than that to produce apparent hepatic/renal damage by cadmium ingestion. Because CdCl2 administration increased the cerebral concentration of oxidized glutathione, we suggest cadmium-induced sleep as a response for oxidative stress clearance. We propose that facilitated non-REM sleep could be a behavioral marker for CdCl2 poisoning.

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