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Alessia Formigari, Elisa Gregianin and Paola Irato The effect of zinc and the role of p53 in copper-induced cellular stress responses Journal of Applied Toxicology 33

Article first published online: 11 FEB 2013 | DOI: 10.1002/jat.2854

Metals can cause an increase in reactive oxygen species (ROS) accumulation resulting in programmed cell death. The exact role that zinc (Zn) plays in the regulation of apoptosis remains ambiguous. Intracellular free Zn modulates p53 activity and stability, excess Zn alters p53 protein structure and down-regulates binding to DNA. Copper (Cu) accumulation causes apoptosis that is mediated by DNA damage and subsequent p53 activation. This review discusses a central role of Zn and of p53 in cellular stress responses induced by redox active biometal Cu.

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