Xianyin Lai, Mangilal Agarwal, Yuri M. Lvov, Chetan Pachpande, Kody Varahramyan and Frank A. Witzmann Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture Journal of Applied Toxicology 33
In view of their potential application in oral drug delivery, we investigated the effect of halloysite nanotubes in an in vitro model of the large intestine. Toxicity tests and label-free quantitative mass spectrometric analysis indicate that halloysite exhibits a high degree of biocompatibility characterized by an absence of cytotoxicity, despite elevated proinflammatory cytokine release. Bioinformatic analysis of differentially expressed protein profiles suggest that halloysite stimulates processes related to cell growth and proliferation, subtle responses to cell infection, irritation and injury, enhanced antioxidant capability, and an overall adaptive response to exposure.
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