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Sabry M. Attia, Abdelkader E. Ashour and Saleh A. Bakheet Comet-FISH studies for evaluation of genetic damage of citalopram in somatic cells of the mouse Journal of Applied Toxicology 33

Version of Record online: 12 FEB 2013 | DOI: 10.1002/jat.2859

This study was designed to evaluate the genotoxicity of citalopram at the recommended human doses in somatic cells of mice. Mice exposed to citalopram at varying oral doses of 12 or 24 mg/kg for 7 days, exhibited significant increase in the level of DNA-strand breaking and micronuclei formation. Furthermore, by FISH analysis with the centromeric DNA-probe for erythrocyte micronuclei it could be shown that citalopram is aneugen as well as clastogen in somatic cells in vivo.

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