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Pius Joseph, Christina Umbright and Rajendran Sellamuthu Blood transcriptomics: applications in toxicology Journal of Applied Toxicology 33

Version of Record online: 1 MAR 2013 | DOI: 10.1002/jat.2861

A vast majority of toxic agents target internal organs for their toxicity. The difficulty in obtaining human internal target organs to determine toxicity is a major obstacle in preventing diseases potentially resulting from exposure to toxic agents. Peripheral blood gene expression profiling has been hypothesized as a practical, highly sensitive and mechanistically relevant surrogate approach to determine target organ toxicity. Recent developments in this emerging toxicology research area, with a special emphasis on hepatotoxicity and pulmonary toxicity, are discussed in this review article.

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