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Sónia Fraga, Helena Faria, Maria Elisa Soares, José Alberto Duarte, Leonor Soares, Eulália Pereira, Cristiana Costa-Pereira, João Paulo Teixeira, Maria de Lourdes Bastos and Helena Carmo Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells Journal of Applied Toxicology 33

Article first published online: 25 MAR 2013 | DOI: 10.1002/jat.2865

This study comparatively evaluated the influence of surface coating [citrate(Cit) vs 11-mercaptoundecanoic acid(11-MUA)] on the uptake and toxicity of gold nanoparticles(AuNPs) in HepG2 cells. Both Cit- and MUA-AuNPs were observed either inside intracellular endosomes or in intercellular spaces. Under the tested conditions, they did not induce cytotoxicity. However, an inverse concentration-dependent increase of DNA damage was observed in Cit-AuNPs- but not in MUA-AuNPs-exposed cells. These data demonstrate the impact of surface properties in the biocompatibility and safety of AuNPs.

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