Guoqing Qian, Lili Tang, Xia Guo, Franklin Wang, Michael E. Massey, Jianjia Su, Tai L. Guo, Jonathan H. Williams, Timothy D. Phillips and Jia-Sheng Wang Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats Journal of Applied Toxicology
Effects of AFB1 on splenic lymphocyte phenotypes and cytokine expression were investigated in male F344 rats. Single-dose exposure to AFB1 decreased expression of CD8+ T cells and CD3-CD8a+ NK cells. Expressions of IL-4 and IFN-γ by CD4+ T cells, IL-4 and IFN-γ by CD8a+ cells, and TNF-α by NK cells were also inhibited; Repeated AFB1 exposure significantly decreased expression of IL-4 by CD4+ T cells and significantly increased expressions of pro-IFN-γ by CD4+ T cells and TNF-α by NK cells.
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