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Guoqing Qian, Lili Tang, Xia Guo, Franklin Wang, Michael E. Massey, Jianjia Su, Tai L. Guo, Jonathan H. Williams, Timothy D. Phillips and Jia-Sheng Wang Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats Journal of Applied Toxicology 34

Version of Record online: 19 MAR 2013 | DOI: 10.1002/jat.2866

Effects of AFB1 on splenic lymphocyte phenotypes and cytokine expression were investigated in male F344 rats. Single-dose exposure to AFB1 decreased expression of CD8+ T cells and CD3CD8a+ NK cells. Expressions of IL-4 and IFN-γ by CD4+ T cells, IL-4 and IFN-γ by CD8a+ cells, and TNF-α by NK cells were also inhibited; Repeated AFB1 exposure significantly decreased expression of IL-4 by CD4+ T cells and significantly increased expressions of pro-IFN-γ by CD4+ T cells and TNF-α by NK cells.

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