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Yoko Nishimura, Yuji Morikawa, Chiaki Kondo, Yutaka Tonomura, Ryou Fukushima, Mikinori Torii and Takeki Uehara Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies Journal of Applied Toxicology 33

Version of Record online: 4 APR 2013 | DOI: 10.1002/jat.2867

Cardiotoxicity is an important issue in drug development. In the present study, we focused on 8 genes (Spp1, Fhl1, Timp1, Serpine1, Bcat1, Lmcd1, Rnd1 and Tgfb2) as candidate genomic biomarkers for cardiotoxicity in rats, and constructed an optimized support vector machine (SVM) model that was composed of Spp1 and Timp1. This multi-gene model exhibited advantages over classic tools commonly used for cardiotoxicity evaluations in rats, and the application of the model could potentially lead to the production of safer drugs.

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