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Andreas Natsch, Cindy A. Ryan, Leslie Foertsch, Roger Emter, Joanna Jaworska, Frank Gerberick and Petra Kern A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation Journal of Applied Toxicology 33

Article first published online: 9 APR 2013 | DOI: 10.1002/jat.2868

Alternative tests for skin sensitization under prevalidation address three endpoints: surface marker expression on dendritic cell lines, peptide reactivity and activation of Nrf2. Here we report a database on 145 chemicals measured in a dendritic cell activation test, the direct peptide reactivity assays and the KeratinoSensTM assay. This comprehensive database may serve to develop a data-driven integrated testing strategy and serve as reference database when benchmarking new molecules with in vitro based read-across.

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