Joanna Jaworska, Yuri Dancik, Petra Kern, Frank Gerberick and Andreas Natsch Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice Journal of Applied Toxicology 33
The current challenge in safety assessments is to find ways to integrate mechanistic insight, in vitro data, in silico and in chemico information to predict in vivo effects. This study follows up on our proof of concept work and presents an updated Integrated Testing Strategy (ITS) to assess skin sensitization potency. The refined ITS predicted correctly 95% and 86% of chemicals in a test set (n = 21) for hazard and local lymph node assay (LLNA) potency classes, respectively. The study includes a detailed validation analysis and illustrations of practical applications.
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