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Piper Reid Hunt, Bryce J. Marquis, Katherine M. Tyner, Sean Conklin, Nicholas Olejnik, Bryant C. Nelson and Robert L. Sprando Nanosilver suppresses growth and induces oxidative damage to DNA in Caenorhabditis elegans Journal of Applied Toxicology 33

Version of Record online: 1 MAY 2013 | DOI: 10.1002/jat.2872

Studies on the effects of nanomaterial exposure in mammals are limited, and new methods for rapid risk assessment of nanomaterials are urgently required. The utility of C. elegans as an alternative model for toxicity screens was evaluated using 10 nanometer silver (10nmAg). Consistent with studies using mammalian in vitro and in vivo models, 10nmAg at 10 μg ml-1 reduced growth and induced oxidative damage to DNA, and ionic silver was found to be more toxic than 10nmAg to C. elegans.

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