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Xia Gong, Li Zhang, Rong Jiang, Chang-Dong Wang, Xin-Ru Yin and Jing-Yuan Wan Hepatoprotective effects of syringin on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice Journal of Applied Toxicology 34

Version of Record online: 26 APR 2013 | DOI: 10.1002/jat.2876

The aim of this study was to investigate the effects and mechanisms of syringin on lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced fulminant hepatic failure (FHF) in mice. Pretreatment mice with syringin alleviated LPS/D-GalN-induced mortality and liver injury, inhibited hepatocellular apoptosis, reduced hepatic tissues tumor necrosis factor-a (TNF-α) production, and NF-kB activation. Our results indicated that syringin might alleviate the FHF induced by LPS/D-GalN through inhibiting NF-kB activation to reduce TNF-α production.

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