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Anxin Wang, Kefeng Pu, Bing Dong, Yang Liu, Liming Zhang, Zhijun Zhang, Wei Duan and Yimin Zhu Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells Journal of Applied Toxicology 33

Article first published online: 18 JUN 2013 | DOI: 10.1002/jat.2877

The cytotoxicity and genotoxicity of graphene oxide (GO) to human lung fibroblast (HLF) cells have been confirmed by performing methyl thiazolyl tetrazolium (MTT), sub-G1 and comet assays to the GO treated cells. The mechanism of toxic effect of GO was explored through examining the toxicity of modified GOs and oxidative stress of GO treated cells. The results showed that oxidative stress mediated by GO and the electronic charge on the surface of GO might explain the reason of its toxicity.

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