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Åsa Gustafsson, Linda Svensson-Elfsmark, Johnny C. Lorentzen and Anders Bucht Strain differences influence timing and magnitude of both acute and late inflammatory reactions after intratracheal instillation of an alkylating agent in rats Journal of Applied Toxicology 34

Version of Record online: 29 APR 2013 | DOI: 10.1002/jat.2878

Six different inbred rat strains were used to determine whether immune activation and progress of fibrosis after lung exposure of the alkylating agent melphalan are genetically regulated. Results demonstrate that timing and magnitude of airway inflammation and late collagen production in lungs are genetically influenced. Two rat strains which developed marked fibrosis also contained increased levels of cytotoxic T cells and natural killer (NK) cells in airways, suggesting that susceptibility to develop lung fibrosis is associated with high cytotoxic cell responses.

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