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Etsuko Sugai, Wataru Yoshioka, Masaki Kakeyama, Seiichiroh Ohsako and Chiharu Tohyama In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates dysregulation of the lipid metabolism in mouse offspring fed a high-calorie diet Journal of Applied Toxicology 34

Version of Record online: 10 JUN 2013 | DOI: 10.1002/jat.2881

Pregnant mice were administered an oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on gestational day 12.5 or vehicle, and their male offspring was given either a regular diet or a high calorie diet after weaning. Pronounced signs of dysregulated lipid metabolism with altered gene expression and liver inflammation were found in the vehicle and high-calorie diet group. The TCDD-exposed and high-calorie diet group had no signs of aggravated diabetes, but had dysregulation of lipid metabolism.

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