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Smita Salian-Mehta, Tanvi Doshi and Geeta Vanage Exposure of neonatal rats to the endocrine disrupter Bisphenol A affects ontogenic expression pattern of testicular steroid receptors and their coregulators Journal of Applied Toxicology 34

Article first published online: 26 APR 2013 | DOI: 10.1002/jat.2882

In light of the adverse reports of Bisphenol A (BPA) on reproduction, it was of interest to decipher the effect of neonatal exposure to BPA on Steroid receptors (SRs) and their coregulators in male reproduction. Developmental expressions in testis were analyzed by qPCR and Immunohistochemistry. SRs and coactivators perturbations at transcript and the protein level were observed, whereas corepressor expression remained unaltered in the BPA-exposed groups. These impairments can be a putative mechanism of adversities on fertility caused by BPA.

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