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Simona Clichici, Alexandru Radu Biris, Cornel Catoi, Adriana Filip and Flaviu Tabaran Short-term splenic impact of single-strand DNA functionalized multi-walled carbon nanotubes intraperitoneally injected in rats Journal of Applied Toxicology 34

Article first published online: 16 MAY 2013 | DOI: 10.1002/jat.2883

We investigated the effects of single-strand DNA-multi-walled carbon nanotubes (ss-DNA-MWCNT) on the rat spleen, after intraperitoneal (i.p.) administration. Carbon nanotubes were detected in the spleen using Raman spectroscopy, histopathologic examination, confocal microscopy and transmission electron microscopy (TEM), at different time points after administration. The dynamics of oxidative and nitrosative stress parameters, pro-inflammatory cytokines and the number of cells expressing caspase 3 and proliferating cell nuclear antigen were assessed. Our results indicate that MWCNT translocate progressively in the spleen, determine lymphoid hyperplasia and transient alterations of oxidative stress and inflammation.

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