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Mi-Sun Choi, Han-Jin Park, Jung-Hwa Oh, Eun-Hee Lee, Se-Myo Park and Seokjoo Yoon Nonylphenol-induced apoptotic cell death in mouse TM4 Sertoli cells via the generation of reactive oxygen species and activation of the ERK signaling pathway Journal of Applied Toxicology 34

Version of Record online: 16 MAY 2013 | DOI: 10.1002/jat.2886

Nonylphenol (NP), a representative endocrine disruptor, interferes with reproductive function in aquatic organisms and animals. Although many studies have focused on apoptotic cell death by NP, the fundamental mechanism of NP on apoptosis remains poorly understood. Here, we investigated the molecular mechanism on NP-induced apoptotic cell death in mouse TM4 Sertoli cells. Our results suggest that NP induced apoptotic cell death is mediated via ROS generation and activation of the ERK signaling pathway in TM4 cells.

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