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Shailendra Pratap Singh, Monika Kumari, Srinivas I. Kumari, Mohammed F. Rahman, M. Mahboob and Paramjit Grover Toxicity assessment of manganese oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral exposure Journal of Applied Toxicology 33

Article first published online: 24 MAY 2013 | DOI: 10.1002/jat.2887

Repeated oral doses of manganese oxide NPs and MPs were administered for 28 days to rats. The genotoxicity results demonstrated significant increase in DNA damage in leukocytes, micronuclei and chromosomal aberrations in bone marrow cells after exposure of MnO2-NPs at 1000, 300mg/kg/bw/day and MnO2-MPs at the dose of 1000mg/kgbw/day. Our findings showed significant biochemical and histopathological changes in various tissues. Significant biodistribution was found in all the tissues after treatment with MnO2 NPs and MPs in a dose dependent manner.

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