Diana Dias da Silva, Elisabete Silva and Helena Carmo Combination effects of amphetamines under hyperthermia - the role played by oxidative stress Journal of Applied Toxicology 34
The impact of hyperthermia on the cytotoxicity of combinations of MDMA and three other amphetamines often co-ingested, d-amphetamine, methamphetamine and 4-methylthioamphetamine, was evaluated. In hyperthermia (40.5 °C), amphetamine mixtures produced deleterious effects, even when individual drugs were combined at negligible concentrations. Mixture effects were accurately predicted by concentration addition model. RNS/ROS production, GSH and ATP depletion and mitochondrial impairment were strongly exacerbated under hyperthermia, emphasizing the potential increased risks of ecstasy intake, especially when hyperthermia occurs concurrently with polydrug abuse.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf