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Jena R. Wirth, Margie M. Peden-Adams, Natasha D. White, Gregory D. Bossart and Patricia A. Fair In vitro PFOS exposure on immune endpoints in bottlenose dolphins (Tursiops truncatus) and mice Journal of Applied Toxicology 34

Version of Record online: 30 MAY 2013 | DOI: 10.1002/jat.2891

Following in vitro exposure to environmentally relevant perfluorooctane sulfonate (PFOS) concentrations (0–5 µg ml−1) in dolphin peripheral blood leukocytes (PBLs) and adult female B6C3F1 mouse splenocytes, lymphocyte proliferation and natural cell killer activity was measured. Risk assessment using a parallelogram approach indicated that dolphin PBLs exhibited similar results to correlative field studies; mice were generally more sensitive than dolphins; dolphins were more similar to humans than mice. The parallelogram approach was predictive two-thirds of the time for dolphin response.

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